Vitamin K-induced modification of coagulation phenotype in VKORC1 homozygous deficiency
نویسندگان
چکیده
منابع مشابه
Polymorphisms in VKORC1 and GGCX are not major genetic determinants of vitamin K-dependent coagulation factor activity in Western Germans.
Thromb Haemost 2009; 102: 418–420 Dear Sir, Several vitamin K-dependent coagulation factors require γ-carboxylation for biological activity. This posttranslational modification is performed by the endoplasmatic reticulum (ER) enzyme γ-glutamyl carboxylase (GGCX), which depends on vitamin K hydroquinone as an electron donor. In this process, vitamin K hydroquinone is oxidised to vitamin K epoxid...
متن کاملVitamin K Deficiency Disease
Vitamin Kdeficiency bleeding (VKDB) previously known as hemorrhagic disease of the newborn has been classified as Early (0-24hrs), Classic (2-7 days) and Late (1-6 months). Child birth following the maternal ingestion of anti-epileptic drugs such as Phenytoin, is liable to result in early VKDB as well as bone changes in the fetus. Other maternal risk factors for VKDB include medications such as...
متن کاملA case report of temporary and acquired vitamin K-dependent clotting factor deficiency without any response to administrated vitamin K
Abstract Background and Objectives Vitamin K-dependent clotting factor deficiency (VKCFD) is usually an acquired problem due to liver disease, malabsorption, and overdose of warfarin. In the present paper the significance and role of vitamin K-dependent coagulation factors in menorrhagia were evaluated. Case We present a rare case of 43 year woman with acquired vitamin K deficiency and se...
متن کاملSevere coagulation defect due to a dietary deficiency of vitamin K.
A patient with multiple injuries developed a severe coagulation defect due to a deficiency of vitamin K. None of the usual predisposing factors was present and the patient's diet was very poor. Dietary deficiency of vitamin K and the importance of antibiotic therapy in its production are discussed.
متن کاملTreatment of vitamin K-dependent coagulation factor deficiency and subarachnoid hemorrhage.
BACKGROUND In adults, vitamin K-dependent coagulation factor deficiency (VKCFD) increases in the recent years. We treated a VKCFD patient with subarachnoid hemorrhage, with favorable outcomes. METHODS A 19-year-old male student with VKCFD was treated at our hospital. The initial treatment was injection of a large dose of vitamin K and fresh plasma, and then with oral high dose of vitamin K4. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2008
ISSN: 1538-7933
DOI: 10.1111/j.1538-7836.2008.02934.x